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KMID : 1145520160020010022
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 1 p.22 ~ p.36
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Chelators for 68Ga radiopharmaceuticals
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Seelam Sudhakara Reddy
Lee Yun-Sang
Jeong Jae-Min
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Abstract
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68Ga is a promising radionuclide for positron emission tomography (PET). It is a generator-produced (68Ge/68Ga-generator) radionuclide with a half-life of 68 min. The employment of 68Ga for basic research and clinical applications is growing exponentially. Bifunctional chelators (BFCs) that can be efficiently radiolabeled with 68Ga to yield complexes with good in vivo stability are needed. Given the practical advantages of 68Ga in PET applications, gallium complexes are gaining increasing attention in biomedical imaging. However, new 68Ga-labeled radiopharmaceuticals that can replace 18F-labeled agents like [18F]fluorodeoxyglucose (FDG) are needed. The majority of 68Ga-labeled derivatives currently in use consist of peptide agents, but the development of other agents, such as amino acid or nitroimidazole derivatives and glycosylated human serum albumin, is being actively pursued in many laboratories. Thus, the availability of new 68Ga-labeled radiopharmaceuticals with high impact is expected in the near future. Here, we present an overview of the different new classes of chelators for application in molecular imaging using 68Ga PET.
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KEYWORD
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68Ga, Radiochemistry, Coordination chemistry, Bifunctional chelators, Cyclic and acyclic chelators
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